Harnett, M. W. and Harnett, W. (2017) Can parasitic worms cure the modern world's ills? Trends in Parasitology, 33(9), pp. 694-705. (doi: 10.1016/j.pt.2017.05.007) (PMID:28606411)
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Abstract
There has been increasing recognition that the alarming surge in allergy and autoimmunity in the industrialised and developing worlds shadows the rapid eradication of pathogens, such as parasitic helminths. Appreciation of this has fuelled an explosion in research investigating the therapeutic potential of these worms. This review considers the current state-of-play with a particular focus on exciting recent advances in the identification of potential novel targets for immunomodulation that can be exploited therapeutically. Furthermore, we contemplate the prospects for designing worm-derived immunotherapies for an ever-widening range of inflammatory diseases, including, for example, obesity, cardiovascular disease, and ageing as well as neurodevelopmental disorders like autism.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Harnett, Professor Margaret and Harnett, Professor William |
Authors: | Harnett, M. W., and Harnett, W. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Trends in Parasitology |
Publisher: | Elsevier |
ISSN: | 1471-4922 |
ISSN (Online): | 1471-5007 |
Published Online: | 09 June 2017 |
Copyright Holders: | Copyright © 2017 Elsevier Ltd. |
First Published: | First published in Trends in Parasitology 33(9): 694-705 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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