Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism

Bruzelius, M. et al. (2014) Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism. Thrombosis Research, 134(2), pp. 426-432. (doi:10.1016/j.thromres.2014.03.054) (PMID:24745723)

Bruzelius, M. et al. (2014) Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism. Thrombosis Research, 134(2), pp. 426-432. (doi:10.1016/j.thromres.2014.03.054) (PMID:24745723)

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Abstract

Introduction: We investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case–control study (n = 2753) from Sweden. Materials and Methods: 39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression. Results: Only rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n = 7181). Conclusions: It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Strawbridge, Dr Rona
Authors: Bruzelius, M., Strawbridge, R. J., Trégouët, D.-A., Wiggins, K. L., Gertow, K., Sabater-Lleal, M., Öhrvik, J., Bergendal, A., Silveira, A., Sundström, A., Kieler, H., Syvänen, A.-C., Smith, N. L., Morange, P.-E., Odeberg, J., and Hamsten, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Thrombosis Research
Publisher:Elsevier
ISSN:0049-3848
ISSN (Online):1879-2472
Published Online:04 April 2014

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