Numerous genes in loci associated with body fat distribution are linked to adipose function

Dahlman, I., Rydén, M., Brodin, D., Grallert, H., Strawbridge, R. J. and Arner, P. (2016) Numerous genes in loci associated with body fat distribution are linked to adipose function. Diabetes, 65(2), pp. 433-437. (doi:10.2337/db15-0828) (PMID:26798124)

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Abstract

Central fat accumulation is a strong risk factor for type 2 diabetes. Genome-wide association studies have identified numerous loci associated with body fat distribution. The objectives of the current study are to examine whether genes in genetic loci linked to fat distribution can be linked to fat cell size and number (morphology) and/or adipose tissue function. We show, in a cohort of 114 women, that almost half of the 96 genes in these loci are indeed associated with abdominal subcutaneous adipose tissue parameters. Thus, adipose mRNA expression of the genes is strongly related to adipose morphology, catecholamine-induced lipid mobilization (lipolysis), or insulin-stimulated lipid synthesis in adipocytes (lipogenesis). In conclusion, the genetic influence on body fat distribution could be mediated via several specific alterations in adipose tissue morphology and function, which in turn may influence the development of type 2 diabetes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Strawbridge, Dr Rona
Authors: Dahlman, I., Rydén, M., Brodin, D., Grallert, H., Strawbridge, R. J., and Arner, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Diabetes
Publisher:American Diabetes Association
ISSN:0012-1797
ISSN (Online):1939-327X
Published Online:21 January 2016

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