Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF

Huffman, J. E. et al. (2015) Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. Blood, 126(11), e19-e29. (doi:10.1182/blood-2015-02-624551) (PMID:26105150) (PMCID:PMC4566813)

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Abstract

Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants with larger effects. The aim of this study was to identify low-frequency (minor allele frequency [MAF] ≥0.01 and <0.05) and rare (MAF <0.01) variants that influence plasma concentrations of these 4 hemostatic factors by meta-analyzing exome chip data from up to 76 000 participants of 4 ancestries. We identified 12 novel associations of low-frequency (n = 2) and rare (n = 10) variants across the fibrinogen, FVII, FVIII, and vWF traits that were independent of previously identified associations. Novel loci were found within previously reported genes and had effect sizes much larger than and independent of previously identified common variants. In addition, associations at KCNT1, HID1, and KATNB1 identified new candidate genes related to hemostasis for follow-up replication and functional genomic analysis. Newly identified low-frequency and rare-variant associations accounted for modest amounts of trait variance and therefore are unlikely to increase predicted trait heritability but provide new information for understanding individual variation in hemostasis pathways.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Strawbridge, Dr Rona
Authors: Huffman, J. E., de Vries, P. S., Morrison, A. C., Sabater-Lleal, M., Kacprowski, T., Auer, P. L., Brody, J. A., Chasman, D. I., Chen, M.-H., Guo, X., Lin, L.-A., Marioni, R. E., Muller-Nurasyid, M., Yanek, L. R., Pankratz, N., Grove, M. L., de Maat, M. P. M., Cushman, M., Wiggins, K. L., Qi, L., Sennblad, B., Harris, S. E., Polasek, O., Riess, H., Rivadeneira, F., Rose, L. M., Goel, A., Taylor, K. D., Teumer, A., Uitterlinden, A. G., Vaidya, D., Yao, J., Tang, W., Levy, D., Waldenberger, M., Becker, D. M., Folsom, A. R., Giulianini, F., Greinacher, A., Hofman, A., Huang, C.-C., Kooperberg, C., Silveira, A., Starr, J. M., Strauch, K., Strawbridge, R. J., Wright, A. F., McKnight, B., Franco, O. H., Zakai, N., Mathias, R. A., Psaty, B. M., Ridker, P. M., Tofler, G. H., Volker, U., Watkins, H., Fornage, M., Hamsten, A., Deary, I. J., Boerwinkle, E., Koenig, W., Rotter, J. I., Hayward, C., Dehghan, A., Reiner, A. P., O'Donnell, C. J., and Smith, N. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Blood
Publisher:American Society of Hematology
ISSN:0006-4971
ISSN (Online):1528-0020
Published Online:10 September 2015

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