Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium

Skaaby, T. et al. (2017) Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Scientific Reports, 7, 2224. (doi:10.1038/s41598-017-01977-w) (PMID:28533558) (PMCID:PMC5440386)

[img]
Preview
Text
140893.pdf - Published Version
Available under License Creative Commons Attribution.

1MB

Abstract

Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of exposures to examine causal effects. We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730. We included 231,020 participants from 22 population-based studies. Observational analyses showed that current vs never smokers had lower risk of hay fever (odds ratio (OR) = 0·68, 95% confidence interval (CI): 0·61, 0·76; P < 0·001) and allergic sensitization (OR = 0·74, 95% CI: 0·64, 0·86; P < 0·001), but similar asthma risk (OR = 1·00, 95% CI: 0·91, 1·09; P = 0·967). Mendelian randomization analyses in current smokers showed a slightly lower risk of hay fever (OR = 0·958, 95% CI: 0·920, 0·998; P = 0·041), a lower risk of allergic sensitization (OR = 0·92, 95% CI: 0·84, 1·02; P = 0·117), but higher risk of asthma (OR = 1·06, 95% CI: 1·01, 1·11; P = 0·020) per smoking-increasing allele. Our results suggest that smoking may be causally related to a higher risk of asthma and a slightly lower risk of hay fever. However, the adverse events associated with smoking limit its clinical significance.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McConnachie, Dr Alex and McSharry, Dr Charles and Barry, Dr Sarah and Sattar, Professor Naveed
Authors: Skaaby, T., Taylor, A. E., Jacobsen, R. K., Paternoster, L., Thuesen, B. H., Ahluwalia, T. S., Larsen, S. C., Zhou, A., Wong, A., Gabrielsen, M. E., Bjorngaard, J. H., Flexeder, C., Mannisto, S., Hardy, R., Kuh, D., Barry, S. J., Mollehave, L. T., Cerqueira, C., Friedrich, N., Bonten, T. N., Noordam, R., Mook-Kanamori, D. O., Taube, C., Jessen, L. E., McConnachie, A., Sattar, N., Upton, M., McSharry, C., Bonnelykke, K., Bisgaard, H., Schulz, H., Strauch, K., Meitinger, T., Peters, A., Grallert, H., Nohr, E. A., Kivimaki, M., Kumari, M., Volker, U., Nauck, M., Volzke, H., Power, C., Hypponen, E., Hansen, T., Jorgensen, T., Pedersen, O., Salomaa, V., Grarup, N., Langhammer, A., Romundstad, P. R., Skorpen, F., Kaprio, J., Munafo, M. R., and Linneberg, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Published Online:22 May 2017

University Staff: Request a correction | Enlighten Editors: Update this record