Bourquin, Y., Reboud, J. , Wilson, R. , Zhang, Y. and Cooper, J. M. (2011) Integrated immunoassay using tuneable surface acoustic waves and lensfree detection. Lab on a Chip, 11(16), p. 2725. (doi: 10.1039/C1LC20320G) (PMID:21725557)
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Abstract
The diagnosis of infectious diseases in the Developing World is technologically challenging requiring complex biological assays with a high analytical performance, at minimal cost. By using an opto-acoustic immunoassay technology, integrating components commonly used in mobile phone technologies, including surface acoustic wave (SAW) transducers to provide pressure driven flow and a CMOS camera to enable lensfree detection technique, we demonstrate the potential to produce such an assay. To achieve this, antibody functionalised microparticles were manipulated on a low-cost disposable cartridge using the surface acoustic waves and were then detected optically. Our results show that the biomarker, interferon-γ, used for the diagnosis of diseases such as latent tuberculosis, can be detected at pM concentrations, within a few minutes (giving high sensitivity at a minimal cost).
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Wilson, Dr Robert and Cooper, Professor Jonathan and Reboud, Professor Julien |
| Authors: | Bourquin, Y., Reboud, J., Wilson, R., Zhang, Y., and Cooper, J. M. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Lab on a Chip |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1473-0197 |
| ISSN (Online): | 1473-0189 |
| Published Online: | 01 July 2011 |
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