Vos, S. J.B. et al. (2017) Modifiable risk factors for prevention of dementia in midlife, late life and the oldest-old: validation of the LIBRA index. Journal of Alzheimer's Disease, 58(2), pp. 537-547. (doi: 10.3233/JAD-161208) (PMID:28453475)
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Abstract
Background: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual’s prevention potential for dementia. Objective: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old. Methods: 9,387 non-demented individuals were recruited from the European population-based DESCRIPA study. An individual’s LIBRA index was calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2 y, range 1–16). Results: In midlife (55–69 y, n = 3,256) and late life (70–79 y, n = 4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80–97 y, n = 1,811), higher LIBRA scores did not increase the risk for dementia. Conclusion: LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old.
| Item Type: | Articles |
|---|---|
| Keywords: | Aging, dementia, modifiable risk factors, prevention. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | O'Donnell, Professor Kate |
| Authors: | Vos, S. J.B., van Boxtel, M. P.J., Schiepers, O. J.G., Deckers, K., de Vugt, M., Carrière, I., Dartigues, J.-F., Peres, K., Artero, S., Ritchie, K., Galluzzo, L., Scafato, E., Frisoni, G. B., Huisman, M., Comijs, H. C., Sacuiu, S. F., Skoog, I., Irving, K., O'Donnell, C. A., Verhey, F. R.J., Visser, P. J., and Köhler, S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care |
| Journal Name: | Journal of Alzheimer's Disease |
| Publisher: | IOS Press |
| ISSN: | 1387-2877 |
| ISSN (Online): | 1875-8908 |
| Published Online: | 28 April 2017 |
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