Modifiable risk factors for prevention of dementia in midlife, late life and the oldest-old: validation of the LIBRA index

Vos, S. J.B. et al. (2017) Modifiable risk factors for prevention of dementia in midlife, late life and the oldest-old: validation of the LIBRA index. Journal of Alzheimer's Disease, 58(2), pp. 537-547. (doi:10.3233/JAD-161208) (PMID:28453475)

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Background: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual’s prevention potential for dementia. Objective: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old. Methods: 9,387 non-demented individuals were recruited from the European population-based DESCRIPA study. An individual’s LIBRA index was calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2 y, range 1–16). Results: In midlife (55–69 y, n = 3,256) and late life (70–79 y, n = 4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80–97 y, n = 1,811), higher LIBRA scores did not increase the risk for dementia. Conclusion: LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old.

Item Type:Articles
Keywords:Aging, dementia, modifiable risk factors, prevention.
Glasgow Author(s) Enlighten ID:O'Donnell, Professor Kate
Authors: Vos, S. J.B., van Boxtel, M. P.J., Schiepers, O. J.G., Deckers, K., de Vugt, M., Carrière, I., Dartigues, J.-F., Peres, K., Artero, S., Ritchie, K., Galluzzo, L., Scafato, E., Frisoni, G. B., Huisman, M., Comijs, H. C., Sacuiu, S. F., Skoog, I., Irving, K., O'Donnell, C. A., Verhey, F. R.J., Visser, P. J., and Köhler, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
Journal Name:Journal of Alzheimer's Disease
Publisher:IOS Press
ISSN (Online):1875-8908
Published Online:28 April 2017

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