Environmental conditions can modulate the links among oxidative stress, age, and longevity

Marasco, V., Stier, A. , Boner, W. , Griffiths, K., Heidinger, B. and Monaghan, P. (2017) Environmental conditions can modulate the links among oxidative stress, age, and longevity. Mechanisms of Ageing and Development, 164, pp. 100-107. (doi:10.1016/j.mad.2017.04.012) (PMID:28487181)

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Abstract

Understanding the links between environmental conditions and longevity remains a major focus in biological research. We examined within-individual changes between early- and mid-adulthood in the circulating levels of four oxidative stress markers linked to ageing, using zebra finches (Taeniopygia guttata): a DNA damage product (8-hydroxy-2′-deoxyguanosine; 8-OHdG), protein carbonyls (PC), non-enzymatic antioxidant capacity (OXY), and superoxide dismutase activity (SOD). We further examined whether such within-individual changes differed among birds living under control (ad lib food) or more challenging environmental conditions (unpredictable food availability), having previously found that the latter increased corticosterone levels when food was absent but improved survival over a three year period. Our key findings were: (i) 8-OHdG and PC increased with age in both environments, with a higher increase in 8-OHdG in the challenging environment; (ii) SOD increased with age in the controls but not in the challenged birds, while the opposite was true for OXY; (iii) control birds with high levels of 8-OHdG died at a younger age, but this was not the case in challenged birds. Our data clearly show that while exposure to the potentially damaging effects of oxidative stress increases with age, environmental conditions can modulate the pace of this age–related change.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Marasco, Dr Valeria and Monaghan, Professor Patricia and Boner, Dr Winifred and Stier, Dr Antoine and Griffiths, Mrs Katharine
Authors: Marasco, V., Stier, A., Boner, W., Griffiths, K., Heidinger, B., and Monaghan, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Mechanisms of Ageing and Development
Publisher:Elsevier
ISSN:0047-6374
ISSN (Online):1872-6216
Published Online:06 May 2017
Copyright Holders:Copyright © 2017 Elsevier
First Published:First published in Mechanisms of Ageing and Development 164: 100-107
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
545091ECOTELO - The ecological significance of telomere dynamics:environments, individuals and inheritancePatricia MonaghanEuropean Research Council (ERC)20100317/FP7-268926RI BIODIVERSITY ANIMAL HEALTH & COMPMED