Chronic obstructive pulmonary disease and comorbidities: a large cross-sectional study in primary care

Chetty, U., McLean, G., Morrison, D. , Agur, K., Guthrie, B. and Mercer, S. W. (2017) Chronic obstructive pulmonary disease and comorbidities: a large cross-sectional study in primary care. British Journal of General Practice, 67(658), e321-e328. (doi: 10.3399/bjgp17X690605) (PMID:28450344)

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Background: Chronic obstructive pulmonary disease (COPD) is common, and a major cause of morbidity and mortality worldwide. Recent studies suggest that comorbidities of COPD increase the risk of hospitalisation, polypharmacy, and mortality, but their estimated prevalence varies widely in the literature. Aim: To evaluate the prevalence of 38 physical and mental health comorbidities in people with COPD, and compare findings with those for people without COPD in a large nationally representative dataset. Design and setting: A cross-sectional data analysis on 1 272 685 adults in Scotland from 314 primary care practices. Method Data: on COPD, along with 31 physical and seven mental health comorbidities, were extracted. The prevalence of comorbidities was compared between people who did, and did not, have COPD, standardised by age, sex, and socioeconomic deprivation. Results: From the total sample, 51 928 patients had COPD (4.1%). Of these, 86.0% had at least one comorbidity, compared with 48.9% of people without COPD. Of those with COPD, 22.3% had ≥5 comorbid conditions compared with 4.9% of those who did not have COPD (adjusted odds ratio 2.63, 95% confidence interval = 2.56 to 2.70). In total, 29 of the 31 physical conditions and six of the seven mental health conditions were statistically significantly more prevalent in people who had COPD than those who did not. Conclusion: Patients with COPD have extensive associated comorbidities. There is a real need for guidelines and health care to reflect this complexity, including how to detect those common comorbidities that relate to both physical and mental health, and how best to manage them. Primary care, which is unique in terms of offering expert generalist care, is best placed to provide this integrated approach.

Item Type:Articles
Glasgow Author(s) Enlighten ID:McLean, Dr Gary and Mercer, Professor Stewart and Morrison, Dr Deborah and Chetty, Dr Ula and Agur, Dr Karolina
Authors: Chetty, U., McLean, G., Morrison, D., Agur, K., Guthrie, B., and Mercer, S. W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
Journal Name:British Journal of General Practice
Publisher:Royal College of General Practitioners
ISSN (Online):1478-5242
Published Online:27 April 2017

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
477971Living Well with Multiple MorbidityStewart MercerChief Scientist office (CSO)ARPG/07/1IHW - GENERAL PRACTICE & PRIMARY CARE