The role of leucine in isoprenoid metabolism. Incorporation of [3-13C]leucine and of [2-3H,4-14C]-β,β-dimethylacrylic acid into phytosterols by tissue cultures of Andrographis paniculata

Anastasis, P., Freer, I. M., Overton, K. H., Rycroft, D. S. and Singh, S. B. (1985) The role of leucine in isoprenoid metabolism. Incorporation of [3-13C]leucine and of [2-3H,4-14C]-β,β-dimethylacrylic acid into phytosterols by tissue cultures of Andrographis paniculata. Journal of the Chemical Society: Chemical Communications, 1985(3), pp. 148-149. (doi:10.1039/C39850000148)

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Abstract

[3-13C]Leucine is incorporated into phytosterols by tissue cultures of Andrographis paniculata by breakdown to acetyl-CoA and its subsequent incorporation via (3S)-3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) and mevalonic acid; [2-3H,4-14C]-β,β-dimethylacrylic acid also is not incorporated intact.

Item Type:Articles
Keywords:Natural product chemistry, biosynthesis, NMR spectroscopy.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Rycroft, Dr David
Authors: Anastasis, P., Freer, I. M., Overton, K. H., Rycroft, D. S., and Singh, S. B.
Subjects:Q Science > QD Chemistry
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of the Chemical Society: Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:0022-4936

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