In-silico Characterisation of the Kirkstall QV900 In-Vitro System for Advanced Cell Culture

McGinty, S. , Hyndman, L., Mottram, N., McKee, S. and Webb, S. (2017) In-silico Characterisation of the Kirkstall QV900 In-Vitro System for Advanced Cell Culture. In: 5 th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, PA, USA, 10-12 April 2017, pp. 1174-1177. ISBN 9780956291448

McGinty, S. , Hyndman, L., Mottram, N., McKee, S. and Webb, S. (2017) In-silico Characterisation of the Kirkstall QV900 In-Vitro System for Advanced Cell Culture. In: 5 th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, PA, USA, 10-12 April 2017, pp. 1174-1177. ISBN 9780956291448

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Abstract

We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mcginty, Dr Sean and Hyndman, Miss Lauren
Authors: McGinty, S., Hyndman, L., Mottram, N., McKee, S., and Webb, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Science and Engineering > School of Engineering > Biomedical Engineering
ISSN:2227-3085
ISBN:9780956291448

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