In-silico Characterisation of the Kirkstall QV900 In-Vitro System for Advanced Cell Culture

McGinty, S. , Hyndman, L., Mottram, N. , McKee, S. and Webb, S. (2017) In-silico Characterisation of the Kirkstall QV900 In-Vitro System for Advanced Cell Culture. In: 5 th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, PA, USA, 10-12 April 2017, pp. 1174-1177. ISBN 9780956291448

Abstract

We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.

• Item Type: Conference Proceedings
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mcginty, Dr Sean and Hyndman, Ms Lauren and Mottram, Professor Nigel
• Authors: McGinty, S., Hyndman, L., Mottram, N., McKee, S., and Webb, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Science and Engineering > School of Engineering > Biomedical Engineering; College of Science and Engineering > School of Mathematics and Statistics > Mathematics
• ISSN: 2227-3085
• ISBN: 9780956291448