Use of cortisol and adrenal weight at pediatric postmortem

Morrison, R., Khan, J., Galloway, P., Mcneilly, J., Ahmed, S. F. and Penman, D. (2017) Use of cortisol and adrenal weight at pediatric postmortem. Fetal and pediatric pathology, 36(3), pp. 246-255. (doi: 10.1080/15513815.2017.1307475) (PMID:28394668)

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Abstract

We studied the relationship between adrenal weight and postmortem cortisol level in cases of infant death, and examined use of these measurements in adrenal insufficiency. We analyzed procurator-fiscal postmortem reports in the West of Scotland over a three year period. Combined adrenal weight was expressed as percentage of total body weight (%TBW). Of 106 cases, median (5(th), 95(th)) %TBW was 0.056 (0.025, 0.23) and median plasma cortisol was 8.4 ug/dl (1.0, 47.1). There was no correlation between %TBW and plasma cortisol (r = 0.09, p = 0.4). The lowest and highest plasma cortisol quartile had medians of 1.9 ug/dl (1.0, 3.4) and 34.3 ug/dl (17.3, 71.5), respectively. Infection was present in 6 cases (23.1%) in the lowest quartile and in 16 cases (61.5%) in the highest quartile (p = 0.01). Our results highlight the difficulty in interpretation of cortisol at postmortem and suggest that adrenal weight measurement alone may be insufficient for diagnosis of adrenal insufficiency.

Item Type:Articles
Keywords:Adrenal insufficiency, adrenal weight, autopsy, cortisol, postmortem.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Khan, Mr Jansher and Mcneilly, Dr Jane and Ahmed, Professor Syed Faisal and Galloway, Dr Peter
Authors: Morrison, R., Khan, J., Galloway, P., Mcneilly, J., Ahmed, S. F., and Penman, D.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Fetal and pediatric pathology
Publisher:Taylor and Francis
ISSN:1551-3815
ISSN (Online):1551-3823
Published Online:10 April 2017

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