On the role of leucine in terpenoid metabolism

Anastasis, P., Freer, I., Overton, K. H., Picken, D., Rycroft, D. S. and Singh, S. B. (1987) On the role of leucine in terpenoid metabolism. Journal of the Chemical Society: Perkin Transactions 1, pp. 2427-2436. (doi:10.1039/P19870002427)

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Abstract

Incorporation of [2-13C]-, [3-13C]-, (4R)-[5-13C]- and (4S)-[5-13C]-leucines into paniculide by tissue cultures of Andrographis paniculata shows that (a) (3S)-3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) from leucine breakdown is not incorporated direct into mevalonic acid (MVA) but that (b) both the acetyl-CoA and acetoacetate produced by leucine breakdown via HMG-CoA are subsequently incorporated into HMG-CoA and MVA.

Item Type:Articles
Keywords:Biosynthesis, natural product chemistry, NMR spectroscopy.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Rycroft, Dr David
Authors: Anastasis, P., Freer, I., Overton, K. H., Picken, D., Rycroft, D. S., and Singh, S. B.
Subjects:Q Science > QD Chemistry
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of the Chemical Society: Perkin Transactions 1
Journal Abbr.:J. Chem. Soc., Perkin Trans. 1
Publisher:Royal Society of Chemistry
ISSN:0300-922X
ISSN (Online):2050-8255

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