Autophagy is critically required for DNA repair by homologous recombination

Gillespie, D. A. and Ryan, K. M. (2016) Autophagy is critically required for DNA repair by homologous recombination. Molecular and Cellular Oncology, 3(1), e1030538. (doi:10.1080/23723556.2015.1030538) (PMID:27308547) (PMCID:PMC4845186)

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Abstract

Autophagy delivers damaged cytoplasmic constituents to lysosomes for degradation, thus preserving cellular integrity and protecting against disease. Remarkably, autophagy-deficient cells also exhibit aberrant DNA damage responses with therapeutic implications, such as suppression of checkpoint kinase-1 function, impaired DNA double-strand break repair by homologous recombination, and increased reliance on error-prone non-homologous end-joining for survival.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gillespie, Professor David and Ryan, Professor Kevin
Authors: Gillespie, D. A., and Ryan, K. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Molecular and Cellular Oncology
Publisher:Taylor and Francis
ISSN:2372-3548
ISSN (Online):2372-3556
Published Online:02 October 2015

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