Gillespie, D. A. and Ryan, K. M. (2016) Autophagy is critically required for DNA repair by homologous recombination. Molecular and Cellular Oncology, 3(1), e1030538. (doi: 10.1080/23723556.2015.1030538) (PMID:27308547) (PMCID:PMC4845186)
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Abstract
Autophagy delivers damaged cytoplasmic constituents to lysosomes for degradation, thus preserving cellular integrity and protecting against disease. Remarkably, autophagy-deficient cells also exhibit aberrant DNA damage responses with therapeutic implications, such as suppression of checkpoint kinase-1 function, impaired DNA double-strand break repair by homologous recombination, and increased reliance on error-prone non-homologous end-joining for survival.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Gillespie, Professor David and Ryan, Professor Kevin |
Authors: | Gillespie, D. A., and Ryan, K. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Molecular and Cellular Oncology |
Publisher: | Taylor and Francis |
ISSN: | 2372-3548 |
ISSN (Online): | 2372-3556 |
Published Online: | 02 October 2015 |
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