Shuttling and sorting lipid-modified cargo into the cilia

Stephen, L. A. and Ismail, S. (2016) Shuttling and sorting lipid-modified cargo into the cilia. Biochemical Society Transactions, 44(5), pp. 1273-1280. (doi: 10.1042/BST20160122) (PMID:27911709)

Abstract

Primary cilia are hair-like microtubule-based organelles that can be found on almost all human cell types. Although the cilium is not separated from the cell by membranes, their content is different from that of the cell body and their membrane composition is distinct from that of the plasma membrane. Here, we will introduce a molecular machinery that shuttles and sorts lipid-modified proteins to the cilium, thus contributing in maintaining its distinct composition. The mechanism involves the binding of the GDI-like solubilising factors, uncoordinated (UNC)119a, UNC119b and PDE6D, to the lipid-modified ciliary cargo and the specific release of the cargo in the cilia by the ciliary small G-protein Arl3 in a GTP-dependent manner.

• Item Type: Articles
• Additional Information: S.I.’s laboratory is supported by the CRUK core funding award [A19257].
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ismail, Dr Shehab
• Authors: Stephen, L. A., and Ismail, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Biochemical Society Transactions
• Publisher: Portland Press
• ISSN: 0300-5127
• ISSN (Online): 1470-8752
• Published Online: 19 October 2016
• Copyright Holders: Copyright © 2016 Portland Press
• First Published: First published in Biochemical Society Transactions 44(5):1273-1280
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher