Mahinrad, S., Vriend, A. E., Jukema, J. W., van Heemst, D., Sattar, N. , Blauw, G. J., Macfarlane, P. W., Clark, E. N., de Craen, A. J.M. and Sabayan, B. (2017) Left ventricular hypertrophy and cognitive decline in old age. Journal of Alzheimer's Disease, 58(1), pp. 275-283. (doi: 10.3233/JAD-161150) (PMID:28387665)
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Abstract
Patients with advanced heart failure run a greater risk of dementia. Whether early cardiac structural changes also associate with cognitive decline is yet to be determined. We tested whether left ventricular hypertrophy (LVH) derived from electrocardiogram associates with cognitive decline in older subjects at risk of cardiovascular disease. We included 4,233 participants (mean age 75.2 years, 47.8% male) from PROSPER (PROspective Study of Pravastatin in the Elderly at Risk). LVH was assessed from baseline electrocardiograms by measuring the Sokolow-Lyon index. Higher levels of Sokolow-Lyon index indicate higher degrees of LVH. Cognitive domains involving selective attention, processing speed, and immediate and delayed memory were measured at baseline and repeated during a mean follow-up of 3.2 years. At baseline, LVH was not associated with worse cognitive function. During follow-up, participants with higher levels of LVH had a steeper decline in cognitive function including in selective attention (p = 0.009), processing speed (p = 0.010), immediate memory (p <0.001), and delayed memory (p = 0.002). These associations were independent of cardiovascular risk factors, co-morbidities, and medications. LVH assessed by electrocardiogram associates with steeper decline in cognitive function of older subjects independent of cardiovascular risk factors and co-morbidities. This study provides further evidence on the link between subclinical cardiac structural changes and cognitive decline in older subjects.
| Item Type: | Articles |
|---|---|
| Keywords: | Cardiovascular disease, cognitive function, elderly, left ventricular hypertrophy. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Macfarlane, Professor Peter and Clark, Mrs Elaine and Sattar, Professor Naveed |
| Authors: | Mahinrad, S., Vriend, A. E., Jukema, J. W., van Heemst, D., Sattar, N., Blauw, G. J., Macfarlane, P. W., Clark, E. N., de Craen, A. J.M., and Sabayan, B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre |
| Journal Name: | Journal of Alzheimer's Disease |
| Publisher: | IOS Press |
| ISSN: | 1387-2877 |
| ISSN (Online): | 1875-8908 |
| Published Online: | 03 May 2017 |
| Copyright Holders: | Copyright © 2017 The Authors |
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