Left ventricular hypertrophy and cognitive decline in old age

Mahinrad, S., Vriend, A. E., Jukema, J. W., van Heemst, D., Sattar, N. , Blauw, G. J., Macfarlane, P. W., Clark, E. N., de Craen, A. J.M. and Sabayan, B. (2017) Left ventricular hypertrophy and cognitive decline in old age. Journal of Alzheimer's Disease, 58(1), pp. 275-283. (doi:10.3233/JAD-161150) (PMID:28387665)

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Abstract

Patients with advanced heart failure run a greater risk of dementia. Whether early cardiac structural changes also associate with cognitive decline is yet to be determined. We tested whether left ventricular hypertrophy (LVH) derived from electrocardiogram associates with cognitive decline in older subjects at risk of cardiovascular disease. We included 4,233 participants (mean age 75.2 years, 47.8% male) from PROSPER (PROspective Study of Pravastatin in the Elderly at Risk). LVH was assessed from baseline electrocardiograms by measuring the Sokolow-Lyon index. Higher levels of Sokolow-Lyon index indicate higher degrees of LVH. Cognitive domains involving selective attention, processing speed, and immediate and delayed memory were measured at baseline and repeated during a mean follow-up of 3.2 years. At baseline, LVH was not associated with worse cognitive function. During follow-up, participants with higher levels of LVH had a steeper decline in cognitive function including in selective attention (p = 0.009), processing speed (p = 0.010), immediate memory (p <0.001), and delayed memory (p = 0.002). These associations were independent of cardiovascular risk factors, co-morbidities, and medications. LVH assessed by electrocardiogram associates with steeper decline in cognitive function of older subjects independent of cardiovascular risk factors and co-morbidities. This study provides further evidence on the link between subclinical cardiac structural changes and cognitive decline in older subjects.

Item Type:Articles
Keywords:Cardiovascular disease, cognitive function, elderly, left ventricular hypertrophy.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Macfarlane, Professor Peter and Clark, Mrs Elaine and Sattar, Professor Naveed
Authors: Mahinrad, S., Vriend, A. E., Jukema, J. W., van Heemst, D., Sattar, N., Blauw, G. J., Macfarlane, P. W., Clark, E. N., de Craen, A. J.M., and Sabayan, B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Journal of Alzheimer's Disease
Publisher:IOS Press
ISSN:1387-2877
ISSN (Online):1875-8908
Published Online:03 May 2017
Copyright Holders:Copyright © 2017 The Authors

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