Diversity and functions of intestinal mononuclear phagocytes

Joeris, T., Müller-Luda, K., Agace, W.W. and Mowat, A. M. (2017) Diversity and functions of intestinal mononuclear phagocytes. Mucosal Immunology, 10(4), pp. 845-864. (doi: 10.1038/mi.2017.22) (PMID:28378807)

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Abstract

The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mφ) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for 'fine tuning' immunological responses within the intestine, a process that may be of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mowat, Professor Allan
Authors: Joeris, T., Müller-Luda, K., Agace, W.W., and Mowat, A. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Mucosal Immunology
Publisher:Nature Publishing Group
ISSN:1933-0219
ISSN (Online):1935-3456
Published Online:05 April 2017
Copyright Holders:Copyright © 2017 Society for Mucosal Immunology
First Published:First published in Mucosal Immunology 10(4):845-864
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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