Schug, Z. T., Vande Voorde, J. and Gottlieb, E. (2016) The metabolic fate of acetate in cancer. Nature Reviews Cancer, 16(11), pp. 708-717. (doi: 10.1038/nrc.2016.87) (PMID:27562461)
Full text not currently available from Enlighten.
Abstract
Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we discuss how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gottlieb, Professor Eyal |
| Authors: | Schug, Z. T., Vande Voorde, J., and Gottlieb, E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Reviews Cancer |
| Publisher: | Nature Publishing Group |
| ISSN: | 1474-175X |
| ISSN (Online): | 1474-1768 |
| Published Online: | 26 August 2016 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details