AMP-activated protein kinase: an ubiquitous signalling pathway with key roles in the cardiovascular system

Salt, I. P. and Hardie, G. (2017) AMP-activated protein kinase: an ubiquitous signalling pathway with key roles in the cardiovascular system. Circulation Research, 120(11), pp. 1825-1841. (doi:10.1161/CIRCRESAHA.117.309633) (PMID:28546359) (PMCID:PMC5447810)

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Abstract

The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy charge is depleted. Over the last 2 decades, it has become apparent that AMPK regulates several other cellular functions and has specific roles in cardiovascular tissues, acting to regulate cardiac metabolism and contractile function, as well as promoting anticontractile, anti-inflammatory, and antiatherogenic actions in blood vessels. In this review, we discuss the role of AMPK in the cardiovascular system, including the molecular basis of mutations in AMPK that alter cardiac physiology and the proposed mechanisms by which AMPK regulates vascular function under physiological and pathophysiological conditions.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salt, Dr Ian
Authors: Salt, I. P., and Hardie, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Circulation Research
Publisher:American Heart Association
ISSN:0009-7330
ISSN (Online):1524-4571
Published Online:25 May 2017
Copyright Holders:Copyright © 2017 American Heart Association
First Published:First published in Circulation Research 120(11): 1825-1841
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
641891Inhibition of endothelial mitogen-activated protein kinases by amp-activated protein kinaseIan SaltBritish Heart Foundation (BHF)PG/13/82/30483RI CARDIOVASCULAR & MEDICAL SCIENCES
587331Inhibition of vascular Stat Signalling by Amp-Activated Protein Kinase (AMPK).Timothy PalmerBritish Heart Foundation (BHF)PG/12/1/29276RI CARDIOVASCULAR & MEDICAL SCIENCES
521381The role of AMP-activated protein kinase in adipocyte glucose transport and insulin signallingIan SaltDiabetes UK (DIABETESUK)09/0003904RI CARDIOVASCULAR & MEDICAL SCIENCES
595391Mechanisms underlying the regulation of endothelial nitric oxide synthesis by glucose and insulin.Ian SaltDiabetes UK (DIABETESUK)12/0004489RI CARDIOVASCULAR & MEDICAL SCIENCES