Salt, I. P. and Hardie, G. (2017) AMP-activated protein kinase: an ubiquitous signalling pathway with key roles in the cardiovascular system. Circulation Research, 120(11), pp. 1825-1841. (doi: 10.1161/CIRCRESAHA.117.309633) (PMID:28546359) (PMCID:PMC5447810)
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139812.pdf - Accepted Version 5MB |
Abstract
The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy charge is depleted. Over the last 2 decades, it has become apparent that AMPK regulates several other cellular functions and has specific roles in cardiovascular tissues, acting to regulate cardiac metabolism and contractile function, as well as promoting anticontractile, anti-inflammatory, and antiatherogenic actions in blood vessels. In this review, we discuss the role of AMPK in the cardiovascular system, including the molecular basis of mutations in AMPK that alter cardiac physiology and the proposed mechanisms by which AMPK regulates vascular function under physiological and pathophysiological conditions.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Salt, Dr Ian |
| Authors: | Salt, I. P., and Hardie, G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Circulation Research |
| Publisher: | American Heart Association |
| ISSN: | 0009-7330 |
| ISSN (Online): | 1524-4571 |
| Published Online: | 25 May 2017 |
| Copyright Holders: | Copyright © 2017 American Heart Association |
| First Published: | First published in Circulation Research 120(11): 1825-1841 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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