Signaling through chemoattractant receptors in Dictyostelium

Chen, M.-Y., Insall, R. H. and Devreotes, P. N. (1996) Signaling through chemoattractant receptors in Dictyostelium. Trends in Genetics, 12(2), pp. 52-57. (doi: 10.1016/0168-9525(96)81400-4) (PMID:8851971)

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Dictyostellium discoideum displays chemoattractant-directed cell migration typical of many higher cell types. Signalling through chemoattractant receptors involves a standard G-protein-linked pathway. Genetic analysis has distinguished essential and dispensable components and demonstrated that some signaling events are independent of G proteins. Genetic analysis has also led to the identification of additional genes involved in chemosensory transduction. Further studies on the newly discovered components and pathways should help in elucidating the molecular mechanisms of eukaryotic chemotaxis.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Insall, Professor Robert
Authors: Chen, M.-Y., Insall, R. H., and Devreotes, P. N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Trends in Genetics
ISSN (Online):1362-4555
Published Online:19 March 1999

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