Small GTPases in Dictyostelium: lessons from a social amoeba

Wilkins, A. and Insall, R. H. (2001) Small GTPases in Dictyostelium: lessons from a social amoeba. Trends in Genetics, 17(1), pp. 41-48. (doi:10.1016/S0168-9525(00)02181-8) (PMID:11163921)

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Abstract

Although the process of sequencing the Dictyostelium genome is not complete, it is already producing surprises, including an unexpectedly large number of Ras- and Rho-subfamily GTPases. Members of these families control a wide variety of cellular processes in eukaryotes, including proliferation, differentiation, cell motility and cell polarity. Comparison of small GTPases from Dictyostelium with those from higher eukaryotes provides an intriguing view of their cellular and evolutionary roles. In particular, although mammalian Ras proteins interact with several signalling pathways, the Dictyostelium pathways appear more linear, with each Ras apparently performing a specific cellular function.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Insall, Professor Robert
Authors: Wilkins, A., and Insall, R. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Trends in Genetics
Publisher:Elsevier
ISSN:0168-9525
ISSN (Online):1362-4555
Published Online:12 January 2001

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