Dictyostelium: an ideal organism for genetic dissection of Ras signalling networks

Chubb, J. R. and Insall, R. H. (2001) Dictyostelium: an ideal organism for genetic dissection of Ras signalling networks. Biochimica et Biophysica Acta: General Subjects, 1525(3), pp. 262-271. (doi:10.1016/S0304-4165(01)00111-8) (PMID:11257439)

Full text not currently available from Enlighten.

Abstract

Signalling pathways based on the small GTPase Ras regulate a multitude of cellular events in eukaryotic cells. Dictyostelium expresses a large and varied family of Ras proteins. It also uses a range of known Ras regulators, in particular RasGEFs, and effectors. The genetic tractability of Dictyostelium, together with the wide range of Ras proteins and regulators, make it an ideal model for the genetic dissection of Ras pathways. This review highlights the recent advances in our understanding of Ras function in Dictyostelium, and considers the implications of these findings for our understanding of eukaryotic signal transduction.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Insall, Professor Robert
Authors: Chubb, J. R., and Insall, R. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Biochimica et Biophysica Acta: General Subjects
Publisher:Elsevier
ISSN:0304-4165
ISSN (Online):1872-8006
Published Online:13 March 2001

University Staff: Request a correction | Enlighten Editors: Update this record