PIP3, PIP2, and cell movement—similar messages, different meanings?

Insall, R. H. and Weiner, O. D. (2001) PIP3, PIP2, and cell movement—similar messages, different meanings? Developmental Cell, 1(6), pp. 743-747. (doi: 10.1016/S1534-5807(01)00086-7) (PMID:11740936) (PMCID:PMC2819114)

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The inositol lipids PI(4,5)P2 and PI(3,4,5)P3 are important regulators of actin polymerization, but their different temporal and spatial dynamics suggest that they perform separate roles. PI(3,4,5)P3 seems to act as an instructive second messenger, inducing local actin polymerization. PI(4,5)P2 appears to be present at too high a concentration and homogenous a distribution to fulfil a similar role. Instead, we suggest that PI(4,5)P2 acts permissively, restricting new actin polymerization to the region of the plasma membrane.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Insall, Professor Robert
Authors: Insall, R. H., and Weiner, O. D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Developmental Cell
ISSN (Online):1878-1551
Published Online:11 December 2001

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