Anatomical segmentation of the human medial prefrontal cortex

Córcoles-Parada, M. et al. (2017) Anatomical segmentation of the human medial prefrontal cortex. Journal of Comparative Neurology, 525(10), pp. 2376-2393. (doi: 10.1002/cne.24212) (PMID:28317116)

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The medial prefrontal areas 32, 24, 14, and 25 (mPFC) form part of the limbic memory system, but little is known about their functional specialization in humans. To add anatomical precision to structural and functional MRI data, we aimed to identify these mPFC subareas in histological preparations of human brain tissue, determine sulci most consistently related with mPFC areal boundaries, and use these sulci to delineate mPFC areas in MRIs. To achieve this, we obtained 3D MRI data from 11 ex vivo hemispheres and processed them for cyto- and myelo-architectonic analysis. The architectonic boundaries of mPFC areas were identified in histology and cortical surface length and volumes were measured. Unfolded maps of histologically determined boundaries were generated to identify the association of mPFC areal boundaries with sulci across cases. This analysis showed that cingulate and superior rostral were the sulci most consistently related to mPFC areal boundaries. Based on presence/absence and anastomosis between such sulci, 6 sulci patterns in the 11 hemispheres were found. A further analysis of 102 hemispheres of in vivo MRI scans (N=51 males, mean±sd 24.1±3.1 years of age) showed similar sulci patterns, which allowed us to delineate the mFPC areas in them. The volumes of mPFC areas across histological, ex vivo and in vivo MRI delineations were comparable and probabilistic maps generated from the MRIs of the102 hemispheres. Probabilistic maps of mPFC areas were registered to MNI space and are available for regional analysis of fMRI data.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Munoz, Dr Monica
Authors: Córcoles-Parada, M., Müller, N.C.J., Ubero, M., Serrano-del-Pueblo, V.M., Mansilla, F., Marcos-Rabal, P., Artacho-Pérula, E., Dresler, M., Insausti, R., Fernández, G., and Muñoz-López, M.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Journal of Comparative Neurology
ISSN (Online):1096-9861
Published Online:20 March 2017
Copyright Holders:Copyright © 2017 Wiley Periodicals, Inc.
First Published:First published in Journal of Comparative Neurology 525(10):2376–2393
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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