Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors

Olson, M. F. (2018) Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors. Small GTPases, 9(3), pp. 203-215. (doi: 10.1080/21541248.2016.1218407) (PMID:27548350) (PMCID:PMC5927519)

[img]
Preview
Text
139300.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial.

1MB

Abstract

The 20 members of the Rho GTPase family are key regulators of a wide-variety of biological activities. In response to activation, they signal via downstream effector proteins to induce dynamic alterations in the organization of the actomyosin cytoskeleton. In this review, post-translational modifications, mechanisms of dysregulation identified in human pathological conditions, and the ways that Rho GTPases might be targeted for chemotherapy will be discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Olson, Professor Michael
Authors: Olson, M. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Small GTPases
Publisher:Taylor & Francis
ISSN:2154-1248
ISSN (Online):2154-1256
Published Online:12 August 2016
Copyright Holders:Copyright © 2016 Michael F. Olson
First Published:First published in Small GTPases 9(3):203-215
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
682111Cysteine oxidation as a regulator of cancer cell motility and invasionMichael OlsonMedical Research Council (MRC)MR/M018776/1ICS - BEATSON INSTITUTE FOR CANCER RES.
694461EPSRC Centre for Multiscale soft tissue mechanics with application to heart & cancerRaymond OgdenEngineering & Physical Sciences Research Council (EPSRC)EP/N014642/1M&S - MATHEMATICS