Olson, M. F. (2018) Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors. Small GTPases, 9(3), pp. 203-215. (doi: 10.1080/21541248.2016.1218407) (PMID:27548350) (PMCID:PMC5927519)
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Abstract
The 20 members of the Rho GTPase family are key regulators of a wide-variety of biological activities. In response to activation, they signal via downstream effector proteins to induce dynamic alterations in the organization of the actomyosin cytoskeleton. In this review, post-translational modifications, mechanisms of dysregulation identified in human pathological conditions, and the ways that Rho GTPases might be targeted for chemotherapy will be discussed.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Olson, Professor Michael |
Authors: | Olson, M. F. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Small GTPases |
Publisher: | Taylor & Francis |
ISSN: | 2154-1248 |
ISSN (Online): | 2154-1256 |
Published Online: | 12 August 2016 |
Copyright Holders: | Copyright © 2016 Michael F. Olson |
First Published: | First published in Small GTPases 9(3):203-215 |
Publisher Policy: | Reproduced under a Creative Commons License |
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