Modelling evolution of saccular cerebral aneurysms

Ventikos, Y. and Watton, P. (2009) Modelling evolution of saccular cerebral aneurysms. Journal of Strain Analysis for Engineering Design, 44(5), pp. 375-389. (doi: 10.1243/03093247JSA492)

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A computational model for the evolution of a saccular cerebral aneurysm of the internal carotid artery is developed. The artery is modelled as a two-layered non-linear elastic cylindrical membrane using a physiologically realistic constitutive model. It is subject to a constant systolic pressure and a physiological axial prestretch. The development of the aneurysm is assumed to be a consequence of the growth and remodelling of its material constituents. The elastinous constituents are prescribed to degrade in a localized circular patch. Microstructural recruitment and fibre concentration variables for the collagen fibres enable the growth and remodelling of collagen fabric to be simulated. The model predicts realistic saccular aneurysm geometries that stabilize in size. It provides the foundations for the development of more sophisticated models of cerebral aneurysm evolution.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Watton, Dr Paul
Authors: Ventikos, Y., and Watton, P.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Journal of Strain Analysis for Engineering Design
ISSN (Online):2041-3130
Published Online:30 April 2009

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