Mathematical modelling of variable porosity coatings for controlled drug release

McGinty, S. , King, D. and Pontrelli, G. (2017) Mathematical modelling of variable porosity coatings for controlled drug release. Medical Engineering and Physics, 45, pp. 51-60. (doi:10.1016/j.medengphy.2017.04.006) (PMID:28461200)

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Abstract

In this paper we investigate the extent to which variable porosity drug-eluting coatings can provide better control over drug release than coatings where the porosity is constant throughout. In particular, we aim to establish the potential benefits of replacing a single-layer with a two-layer coating of identical total thickness and initial drug mass. In our study, what distinguishes the layers (other than their individual thickness and initial drug loading) is the underlying microstructure, and in particular the effective porosity and the tortuosity of the material. We consider the effect on the drug release profile of varying the initial distribution of drug, the relative thickness of the layers and the relative resistance to diffusion offered by each layer’s composition. Our results indicate that the contrast in properties of the two layers can be used as a means of better controlling the release, and that the quantity of drug delivered in the early stages can be modulated by varying the distribution of drug across the layers. We conclude that microstructural and loading differences between multi-layer variable porosity coatings can be used to tune the properties of the coating materials to obtain the desired drug release profile for a given application.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mcginty, Dr Sean and King, Mr David
Authors: McGinty, S., King, D., and Pontrelli, G.
College/School:College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Medical Engineering and Physics
Publisher:Elsevier
ISSN:1350-4533
ISSN (Online):1873-4030
Published Online:29 April 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Medical Engineering and Physics 45: 51-60
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
579501Optimal Design of Drug Eluting StentsSimon KennedyEngineering & Physical Sciences Research Council (EPSRC)EP/J007579/1RI CARDIOVASCULAR & MEDICAL SCIENCES
678901EPSRC DTG 2014Mary Beth KneafseyEngineering & Physical Sciences Research Council (EPSRC)EP/M506539/1RSI - RESEARCH STRATEGY & INNOVATION