Tensin links energy metabolism to extracellular matrix assembly.

Dornier, E. G. and Norman, J. C. (2017) Tensin links energy metabolism to extracellular matrix assembly. Journal of Cell Biology, 216(4), pp. 867-869. (doi: 10.1083/jcb.201702025) (PMID:28325807)

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The regulation of integrin function is key to fundamental cellular processes, including cell migration and extracellular matrix (ECM) assembly. In this issue, Georgiadou et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201609066) report that the metabolic sensor adenosine monophosphate-activated protein kinase influences tensin production to regulate α5β1-integrin and fibrillar adhesion assembly and thus reveal an important connection between energy metabolism and ECM assembly.

Item Type:Articles
Additional Information:Research conducted in the Norman lab funded by Cancer Research UK and Breast Cancer Now.
Glasgow Author(s) Enlighten ID:Norman, Professor James and Dornier, Mr Emmanuel Greg
Authors: Dornier, E. G., and Norman, J. C.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Journal of Cell Biology
Publisher:Rockefeller University Press
ISSN (Online):1540-8140
Published Online:21 March 2017
Copyright Holders:Copyright © 2017 Dornier and Norman
First Published:First published in Journal of Cell Biology 216(4):867-869
Publisher Policy:Reproduced under a Creative Commons License

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