Multi-scale interaction of particulate flow and the artery wall

Halliday, I. et al. (2011) Multi-scale interaction of particulate flow and the artery wall. Medical Engineering and Physics, 33(7), pp. 840-848. (doi: 10.1016/j.medengphy.2010.09.007) (PMID:21036095)

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We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Watton, Dr Paul
Authors: Halliday, I., Atherton, M., Care, C.M., Collins, M.W., Evans, D., Evans, P.C., Hose, D.R., Khir, A.W., König, C.S., Krams, R., Lawford, P.V., Lishchuk, S.V., Pontrelli, G., Ridger, V., Spencer, T.J., Ventikos, Y., Walker, D.C., and Watton, P.N.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Medical Engineering and Physics
ISSN (Online):1873-4030
Published Online:29 October 2010

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