Patients with gout have short telomeres compared with healthy participants: association of telomere length with flare frequency and cardiovascular disease in gout

Vazirpanah, N. et al. (2017) Patients with gout have short telomeres compared with healthy participants: association of telomere length with flare frequency and cardiovascular disease in gout. Annals of the Rheumatic Diseases, 76(7), pp. 1309-1315. (doi:10.1136/annrheumdis-2016-210538) (PMID:28347991)

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Abstract

Aim and background: Chronic inflammation associates with increased senescence, which is a strong predictor for cardiovascular disease. We hypothesised that inflammation accelerates senescence and thereby enhances the risk of cardiovascular disease in gout. Methods: We assessed replicative senescence by quantifying telomere length (TL) in a discovery cohort of 145 Dutch patients with gout and 273 healthy individuals and validated our results in 474 patients with gout and 293 healthy participants from New Zealand. Subsequently, we investigated the effect of cardiovascular disease on TL of all participants. Also, we measured TL of CD4+ and CD8+ T lymphocytes, B lymphocytes, monocytes, natural killer cells and plasmacytoid dendritic cells. Additionally, we assessed the potential temporal difference in TL and telomerase activity. Results: TL in PBMCs of healthy donors decreased over time, reflecting normal ageing. Patients with gout demonstrated shorter telomeres (p=0.001, R2=0.01873). In fact, the extent of telomere erosion in patients with gout was higher at any age compared with healthy counterparts at any age (p<0.0001, R2=0.02847). Patients with gout with cardiovascular disease had the shortest telomeres and TL was an independent risk factor for cardiovascular disease in patients with gout (p=0.001). TL was inversely associated with the number of gouty flares (p=0.005). Conclusions: Patients with gout have shorter telomeres than healthy participants, reflecting increased cellular senescence. Telomere shortening was associated with the number of flares and with cardiovascular disease in people with gout.

Item Type:Articles
Additional Information:JCAB is supported by a VENI Award from the Netherlands Organization for Scientific Research (N.W.O. project number 91614041).
Keywords:Basic and translational research, gout, inflammation, cardiovascular disease.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Broen, Mr Jasper and Shiels, Professor Paul
Authors: Vazirpanah, N., Kienhorst, L.B.E., Van Lochem, E., Wichers, C., Rossato, M., Shiels, P.G., Dalbeth, N., Stamp, L.K., Merriman, T.R., Janssen, M., Radstake, T.R.D.J., and Broen, J.C.A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Annals of the Rheumatic Diseases
Publisher:BMJ Publishing Group
ISSN:0003-4967
ISSN (Online):1468-2060
Published Online:27 March 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Annals of the Rheumatic Diseases 76(7):1309-1315
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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