Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?

Welsh, P. , Grassia, G., Botha, S., Sattar, N. and Maffia, P. (2017) Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? British Journal of Pharmacology, 174(22), pp. 3898-3913. (doi:10.1111/bph.13818) (PMID:28409825) (PMCID:PMC5660005)

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Abstract

Data from basic science experiments is overwhelmingly supportive of the causal role of immune-inflammatory response(s) at the core of atherosclerosis, and therefore the theoretical potential to manipulate the inflammatory response to prevent cardiovascular events. However, extrapolation to humans requires care and we still lack definitive evidence to show that interfering in immune-inflammatory processes may safely lessen clinical atherosclerosis. In this review, we discuss key therapeutic targets in the treatment of vascular inflammation, placing basic research in to a wider clinical perspective, as well as identifying outstanding questions.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maffia, Dr Pasquale and Welsh, Dr Paul and Grassia, Dr Gianluca and Botha, Dr Shani and Sattar, Professor Naveed
Authors: Welsh, P., Grassia, G., Botha, S., Sattar, N., and Maffia, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:British Journal of Pharmacology
Publisher:Wiley
ISSN:0007-1188
ISSN (Online):1476-5381
Published Online:13 April 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in British Journal of Pharmacology 174(22): 3898-3913
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
614711Defining innate and adaptive immune functions of plasmacytoid dendritic cells in atherosclerosis.Pasquale MaffiaBritish Heart Foundation (BHF)PG/12/81/29897III -IMMUNOLOGY
617771BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177RI CARDIOVASCULAR & MEDICAL SCIENCES
682541NanoMATePasquale MaffiaEuropean Commission (EC)661369III -IMMUNOLOGY
644661In Situ Nanoparticle Assemblies for Healthcare Diagnostics and TherapyPasquale MaffiaEngineering & Physical Sciences Research Council (EPSRC)EP/L014165/1III -IMMUNOLOGY
718631Selective targeting of NF-??B by Bcl-3 in the control of vascular injuryGianluca GrassiaTenovus-Scotland (TENOVUS)S15/24III -IMMUNOLOGY

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