Regulation of WASP: PIP2 pipped By Toca-1?

Insall, R. H. and Machesky, L. M. (2004) Regulation of WASP: PIP2 pipped By Toca-1? Cell, 118(2), pp. 140-141. (doi: 10.1016/j.cell.2004.07.005) (PMID:15260983)

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Cdc42 is a key regulator of cell polarity and actin dynamics. One of its effectors, WASP, initiates the assembly of new actin filaments. In this issue of Cell, Ho et al. (2004) show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP. This discovery changes our picture of how small GTPases and multiple other signals converge to stimulate actin polymerization and cell motility.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura and Insall, Professor Robert
Authors: Insall, R. H., and Machesky, L. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cell
ISSN (Online):1097-4172
Published Online:22 July 2004

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