Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway

Kurz, T. , Pintard, L., Willis, J. H., Hamill, D. R., Gönczy, P., Peter, M. and Bowerman, B. (2002) Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science, 295(5558), pp. 1294-1298. (doi: 10.1126/science.1067765) (PMID:11847342)

Abstract

The Nedd8 ubiquitin-like protein modification pathway regulates cell-cycle progression. Our analysis of Nedd8 requirements duringCaenorhabditis elegans embryogenesis indicates that the cytoskeleton is another target. Nedd8 conjugation negatively regulated contractility of the microfilament-rich cell cortex during pronuclear migration and again during cytokinesis. The Nedd8 pathway also was required after meiosis to negatively regulate katanin, a microtubule-severing complex, permitting the assembly of a large mitotic spindle. We propose that Nedd8-modified cullin, as part of an E3 ubiquitin ligase complex, targets katanin for degradation during the transition from meiosis to mitosis.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kurz, Dr Thimo
• Authors: Kurz, T., Pintard, L., Willis, J. H., Hamill, D. R., Gönczy, P., Peter, M., and Bowerman, B.
• College/School: College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Science
• Publisher: American Association for the Advancement of Science
• ISSN: 0036-8075
• ISSN (Online): 1095-9203