The Ras signalling pathway as a target in cancer therapy

Graham, K. and Olson, M. F. (2007) The Ras signalling pathway as a target in cancer therapy. In: Groner, B. (ed.) Targeted Interference with Signal Transduction Events. Series: Recent results in cancer research (172). Springer: Berlin ; New York, pp. 125-153. ISBN 9783540312086 (doi: 10.1007/978-3-540-31209-3_8)

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Abstract

The Ras GTPase proteins and their down-stream effectors regulate specific intracellular signalling pathways involved in numerous biological processes. Their actions directly influence progression through the cell cycle and the delicate balance of pro- and anti-apoptotic factors. The variety of functions controlled by Ras, and the emerging evidence indicating that aberrations in Ras as well as at multiple points in downstream signalling pathways contribute to tumourigenesis, suggest that Ras signal transduction mechanisms have significant potential as anti-cancer therapeutic targets.

Item Type:Book Sections
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Olson, Professor Michael
Authors: Graham, K., and Olson, M. F.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Publisher:Springer
ISBN:9783540312086
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