Visualizing cancer cell chemotaxis and invasion in 2D and 3D

Susanto, O., Muinonen-Martin, A. J., Nobis, M. and Insall, R. H. (2016) Visualizing cancer cell chemotaxis and invasion in 2D and 3D. In: Jin, T. and Hereld, D. (eds.) Chemotaxis. Series: Methods in molecular biology, 1407 (1407). Springer, pp. 217-228. ISBN 9781493934782 (doi:10.1007/978-1-4939-3480-5_17)

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Abstract

We describe three chemotaxis assays—Insall chambers, circular invasion assays, and 3D organotypic assays—that are particularly appropriate for measuring migration of cancer cells in response to gradients of soluble attractants. Each assay has defined advantages, and together they provide the best possible quantitative assessment of cancer chemotaxis.

Item Type:Book Sections
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Susanto, Dr Olivia and Insall, Professor Robert and Muinonen-Martin, Dr Andrew
Authors: Susanto, O., Muinonen-Martin, A. J., Nobis, M., and Insall, R. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Publisher:Springer
ISSN:1064-3745
ISSN (Online):1940-6029
ISBN:9781493934782

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