The therapeutic potential of bacteriocins as protein antibiotics

Behrens, H. M., Six, A., Walker, D. and Kleanthous, C. (2017) The therapeutic potential of bacteriocins as protein antibiotics. Emerging Topics in Life Sciences, 1(1), pp. 65-74. (doi:10.1042/ETLS20160016)

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Abstract

The growing incidence of antibiotic-resistant Gram-negative bacterial infections poses a serious threat to public health. Molecules that have yet to be exploited as antibiotics are potent protein toxins called bacteriocins that are produced by Gram-negative bacteria during competition for ecological niches. This review discusses the state of the art regarding the use for therapeutic purposes of two types of Gram-negative bacteriocins: colicin-like bacteriocins (CLBs) and tailocins. In addition to in vitro data, the potency of eight identified CLBs or tailocins has been demonstrated in diverse animal models of infection with no adverse effects for the host. Although the characteristics of bacteriocins will need further study, results obtained thus far regarding their in vivo potency, immunogenicity and low levels of resistance are encouraging. This leads the way for the development of novel treatments using bacteriocins as protein antibiotics.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Walker, Professor Daniel and Six, Dr Anne
Authors: Behrens, H. M., Six, A., Walker, D., and Kleanthous, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Emerging Topics in Life Sciences
Publisher:Portland Press
ISSN:2397-8554
ISSN (Online):2397-8562
Published Online:21 April 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Emerging Topics in Life Sciences 1(1): 65-74
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
724641Protein Antibiotics: Discovery, mode of action and developmentDaniel WalkerWellcome Trust (WELLCOME)201505/Z/16/ZIII - BACTERIOLOGY