Raman optical activity: an incisive new probe of the structure and dynamics of biomolecules

Barron, L.D., Hecht, L. and Bell, A.F. (1998) Raman optical activity: an incisive new probe of the structure and dynamics of biomolecules. Science Progress, 81(Pt 1), pp. 17-34. (PMID:9567775)

Full text not currently available from Enlighten.

Abstract

Determination of the solution structure and function of biomolecules such as proteins, carbohydrates and nucleic acids remains at the forefront of biomedical research. Thanks to recent developments in instrumentation, biomolecules can now be studied using Raman optical activity (ROA), a novel technique which measures vibrational optical activity in chiral molecules by means of a small difference in the intensity of Raman scattering in right- and left-circularly polarized incident laser light. This article reviews recent progress in the application of ROA to the determination of the solution structure and dynamics of proteins, carbohydrates and nucleic acids.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hecht, Dr Lutz and Barron, Professor Laurence
Authors: Barron, L.D., Hecht, L., and Bell, A.F.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Science Progress
Publisher:Science Reviews 2000 Ltd.
ISSN:0036-8504
ISSN (Online):0036-8504

University Staff: Request a correction | Enlighten Editors: Update this record