Colman, M. A., Sarathy, P. P., MacQuiaide, N. and Workman, A. J. (2016) A new model of the human atrial myocyte with variable T-tubule organization for the study of atrial fibrillation. Computing in Cardiology, 43, pp. 221-224. (doi: 10.23919/CIC.2016.7868719)
|
Text
138263.pdf - Accepted Version 957kB |
Publisher's URL: http://ieeexplore.ieee.org/document/7868719/metrics
Abstract
Atrial fibrillation is the most common arrhythmia, yet treatment strategies are sub-optimal due to incomplete understanding of the underlying mechanisms. Spatiotemporal sub-cellular calcium cycling may play a critical role in the development of alternans and spontaneous activity, which may underlie arrhythmia in the human atria. In this study, we construct a novel electrophysiological model of the human atrial myocyte which incorporates new data on atrial intracellular structure and explicitly accounts for variations in T-tubule organization. The model reproduces spatio-temporal calcium dynamics associated with normal cardiac excitation. In preliminary simulations, the model demonstrates that a loss of T-tubules can promote both alternans and spontaneous calcium waves. The model produced in this study provides novel insight into arrhythmia mechanisms in the human atria and provides a platform for future investigation of proarrhythmic calcium dynamics.
Item Type: | Articles |
---|---|
Additional Information: | Presented at the Computing in Cardiology Conference, Vancouver, BC, Canada, 11-14 Sept 2016 |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Workman, Dr Antony |
Authors: | Colman, M. A., Sarathy, P. P., MacQuiaide, N., and Workman, A. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Computing in Cardiology |
Publisher: | Computing in Cardiology |
ISSN: | 0276-6574 |
ISSN (Online): | 2325-887X |
Copyright Holders: | Copyright © 2016 The Authors |
First Published: | First published in Computing in Cardiology 43:221-224 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record