A new model of the human atrial myocyte with variable T-tubule organization for the study of atrial fibrillation

Colman, M. A., Sarathy, P. P., MacQuiaide, N. and Workman, A. J. (2016) A new model of the human atrial myocyte with variable T-tubule organization for the study of atrial fibrillation. Computing in Cardiology, 43, pp. 221-224. (doi:10.23919/CIC.2016.7868719)

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Abstract

Atrial fibrillation is the most common arrhythmia, yet treatment strategies are sub-optimal due to incomplete understanding of the underlying mechanisms. Spatiotemporal sub-cellular calcium cycling may play a critical role in the development of alternans and spontaneous activity, which may underlie arrhythmia in the human atria. In this study, we construct a novel electrophysiological model of the human atrial myocyte which incorporates new data on atrial intracellular structure and explicitly accounts for variations in T-tubule organization. The model reproduces spatio-temporal calcium dynamics associated with normal cardiac excitation. In preliminary simulations, the model demonstrates that a loss of T-tubules can promote both alternans and spontaneous calcium waves. The model produced in this study provides novel insight into arrhythmia mechanisms in the human atria and provides a platform for future investigation of proarrhythmic calcium dynamics.

Item Type:Articles
Additional Information:Presented at the Computing in Cardiology Conference, Vancouver, BC, Canada, 11-14 Sept 2016
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Workman, Dr Antony
Authors: Colman, M. A., Sarathy, P. P., MacQuiaide, N., and Workman, A. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Computing in Cardiology
Publisher:Computing in Cardiology
ISSN:0276-6574
ISSN (Online):2325-887X
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Computing in Cardiology 43:221-224
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
626321Human atrial action potential alternans and afterdepolarisations: electrophysiological and calcium-cycling mechanisms and effects of myocardial diseaseAntony WorkmanBritish Heart Foundation (BHF)PG/13/31/30156RI CARDIOVASCULAR & MEDICAL SCIENCES