Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology

Varyani, F., Fleming, J. O. and Maizels, R. (2017) Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology. American Journal of Physiology: Gastrointestinal and Liver Physiology, 312(6), G537-G549. (doi:10.1152/ajpgi.00024.2017) (PMID:28302598) (PMCID:5495915)

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Abstract

Helminth parasites are highly prevalent in many low- and middle-income countries, in which inflammatory bowel disease and other immunopathologies are less frequent than in the developed world. Many of the most common helminths establish in the gastrointestinal tract, and can exert counter-inflammatory influences on the host immune system. For these reasons, interest has arisen in how parasites may ameliorate intestinal inflammation and whether these organisms, or products they release, could offer future therapies for immune disorders. In this review, we discuss interactions between helminth parasites and the mucosal immune system, and progress made towards identifying mechanisms and molecular mediators through which it may be possible to attenuate pathology in the intestinal tract.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Fleming, Mr John and Varyani, Dr Fumi and Maizels, Professor Rick
Authors: Varyani, F., Fleming, J. O., and Maizels, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:American Journal of Physiology: Gastrointestinal and Liver Physiology
Publisher:American Physiological Society
ISSN:0193-1857
ISSN (Online):1522-1547
Published Online:16 March 2017
Copyright Holders:Copyright © 2017 The American Physiological Society
First Published:First published in American Journal of Physiology: Gastrointestinal and Liver Physiology 312(6):G537-G549
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
765221Helminths and the Immune System: Regulation, Regulators and ImmunityRichard MaizelsWellcome Trust (WELLCOME)106122/A/14/ZIII - PARASITOLOGY
371799The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOME)104111/Z/14/Z & AIII - PARASITOLOGY