Varyani, F., Fleming, J. O. and Maizels, R. (2017) Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology. American Journal of Physiology: Gastrointestinal and Liver Physiology, 312(6), G537-G549. (doi: 10.1152/ajpgi.00024.2017) (PMID:28302598) (PMCID:5495915)
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Abstract
Helminth parasites are highly prevalent in many low- and middle-income countries, in which inflammatory bowel disease and other immunopathologies are less frequent than in the developed world. Many of the most common helminths establish in the gastrointestinal tract, and can exert counter-inflammatory influences on the host immune system. For these reasons, interest has arisen in how parasites may ameliorate intestinal inflammation and whether these organisms, or products they release, could offer future therapies for immune disorders. In this review, we discuss interactions between helminth parasites and the mucosal immune system, and progress made towards identifying mechanisms and molecular mediators through which it may be possible to attenuate pathology in the intestinal tract.
| Item Type: | Articles |
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| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Fleming, Mr John and Varyani, Dr Fumi and Maizels, Professor Rick |
| Authors: | Varyani, F., Fleming, J. O., and Maizels, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | American Journal of Physiology: Gastrointestinal and Liver Physiology |
| Publisher: | American Physiological Society |
| ISSN: | 0193-1857 |
| ISSN (Online): | 1522-1547 |
| Published Online: | 16 March 2017 |
| Copyright Holders: | Copyright © 2017 The American Physiological Society |
| First Published: | First published in American Journal of Physiology: Gastrointestinal and Liver Physiology 312(6):G537-G549 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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