Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses

Cumberworth, S., Clark, J. J., Kohl, A. and Donald, C. L. (2017) Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses. Cellular Microbiology, 19(5), e12737. (doi:10.1111/cmi.12737) (PMID:28273394) (PMCID:PMC5413821)

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Abstract

The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease. In order to efficiently establish a productive infection in mammalian cells, flaviviruses have developed key strategies to counteract host immune defences, including the type I interferon response. They employ different mechanisms to control interferon signal transduction and effector pathways, and key research generated over the past couple of decades has uncovered new insights into their abilities to actively decrease interferon antiviral activity. Given the lack of antivirals or prophylactic treatments for many flaviviral infections, it is important to fully understand how these viruses affect cellular processes to influence pathogenesis and disease outcome. This review will discuss the strategies mosquito-borne flaviviruses have evolved to antagonise type I interferon mediated immune responses.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Donald, Dr Claire and Clark, Mr Jordan and Kohl, Professor Alain and Cumberworth, Miss Stephanie
Authors: Cumberworth, S., Clark, J. J., Kohl, A., and Donald, C. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cellular Microbiology
Publisher:Wiley
ISSN:1462-5814
ISSN (Online):1462-5822
Published Online:22 March 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Cellular Microbiology 19(5): e12737
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656551Arbovirus interactions with arthropod hostsAlain KohlMedical Research Council (MRC)MC_UU_12014/8MVLS III - CENTRE FOR VIRUS RESEARCH
708681The emergence of Zika virus in Brazil: investigating prevalence and host responses to design preventive strategiesAlain KohlMedical Research Council (MRC)MR/N017552/1MVLS III - CENTRE FOR VIRUS RESEARCH

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