Studies of the T-cell angiotensin receptor using cre-lox technology: an unan-T-cellpated result

Harrison, D. G. and Guzik, T. J. (2012) Studies of the T-cell angiotensin receptor using cre-lox technology: an unan-T-cellpated result. Circulation Research, 110(12), pp. 1543-1545. (doi: 10.1161/CIRCRESAHA.112.271411) (PMID:22679135)

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Abstract

Classically, antigen-presenting cells, displaying antigenic peptides bound to major histocompatibility complexes, activate T cells. Ligation of the major histocompatibility complex with the T-cell receptor is often referred to as “signal 1”, which must be accompanied by costimulation (“Signal 2”), commonly mediated by interaction of CD28 on T cells with B7 ligands on APCs. In addition to these canonical activation signals, T cells also possess “accessory receptors”, which while incapable of activating T cells on their own, direct T cell polarization, proliferation and expression of surface molecules that promote T cell exodus from lymph nodes and migration to sites of inflammation. As examples, exposure of CD4+ cells to both interleukin-6 and transforming growth factor-β promotes formation TH17 cells, which are generally proinflammatory, whereas exposure to transforming growth factor-β alone leads to formation of T-regulatory cells, which are immunosuppressive. Interleukin-12 polarizes CD4+ cells to a TH1 phenotype, whereas interleukin-4 promotes TH2 cytokine production.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Guzik, Professor Tomasz
Authors: Harrison, D. G., and Guzik, T. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Circulation Research
Publisher:American Heart Association
ISSN:0009-7330
ISSN (Online):1524-4571
Published Online:07 June 2012

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