Macrophages come to mind as keys to cognitive decline

Harrison, D.G. and Guzik, T. J. (2016) Macrophages come to mind as keys to cognitive decline. Journal of Clinical Investigation, 126(12), pp. 4393-4395. (doi: 10.1172/JCI91277) (PMID:27841765)

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Cognitive impairment, an underappreciated consequence of hypertension, is linked to cerebral arteriolar disease through poorly defined mechanisms. A study by Faraco et al. in this issue of the JCI points to perturbations of neurovascular unit coupling caused by perivascular macrophages (PVMs) as a cause of hypertension-related cognitive impairment. Angiotensin II (Ang II) was shown to activate PVMs, causing them to produce superoxide and thereby alter the proper functioning of the adjacent arterioles. Faraco and colleagues also show that disruption of the blood-brain barrier occurs in hypertension, allowing circulating Ang II to access PVMs. This study provides important new insight into the role of inflammatory cells in the genesis of vascular dementia.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Guzik, Professor Tomasz
Authors: Harrison, D.G., and Guzik, T. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Clinical Investigation
Publisher:Americal Society for Clinical Investigation
ISSN (Online):1558-8238
Copyright Holders:Copyright © 2016 The AuthorsASCI
First Published:First published in Journal of Clinical Investigation 126(12):4393-4395
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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