Magnetoencephalography as a tool in psychiatric research: current status and perspective

Uhlhaas, P. J. , Liddle, P., Linden, D. E.J., Nobre, A. C., Singh, K. D. and Gross, J. (2017) Magnetoencephalography as a tool in psychiatric research: current status and perspective. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(3), pp. 235-244. (doi: 10.1016/j.bpsc.2017.01.005) (PMID:28424797) (PMCID:PMC5387180)

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Abstract

The application of neuroimaging to provide mechanistic insights into circuit dysfunctions in major psychiatric conditions and the development of biomarkers are core challenges in current psychiatric research. In this review, we propose that recent technological and analytic advances in Magnetoencephalography (MEG), a technique which allows the measurement of neuronal events directly and non-invasively with millisecond resolution, provides novel opportunities to address these fundamental questions. Because of its potential in delineating normal and abnormal brain dynamics, we propose that MEG provides a crucial tool to advance our understanding of pathophysiological mechanisms of major neuropsychiatric conditions, such as Schizophrenia, Autism Spectrum Disorders, and the dementias. In our paper, we summarize the mechanisms underlying the generation of MEG signals and the tools available to reconstruct generators and underlying networks using advanced source-reconstruction techniques. We then survey recent studies that have utilized MEG to examine aberrant rhythmic activity in neuropsychiatric disorders. This is followed by links with preclinical research, which have highlighted possible neurobiological mechanisms, such as disturbances in excitation/inhibition parameters, which could account for measured changes in neural oscillations. In the final section of the paper, challenges as well as novel methodological developments are discussed which could pave the way for a widespread application of MEG in translational research with the aim of developing biomarkers for early detection and diagnosis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter and Gross, Professor Joachim
Authors: Uhlhaas, P. J., Liddle, P., Linden, D. E.J., Nobre, A. C., Singh, K. D., and Gross, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Publisher:Elsevier
ISSN:2451-9022
Published Online:30 January 2017
Copyright Holders:Copyright © 2016 Society of Biological Psychiatry
First Published:First published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2(3):235-244
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
597051Natural and modulated neural communication: State-dependent decoding and driving of human Brain Oscillations.Joachim GrossWellcome Trust (WELLCOME)098433/Z/12/ZINP - CENTRE FOR COGNITIVE NEUROIMAGING
586511Building multi-site clinical research capacity in Magnetoencephalography (MEG)Joachim GrossMedical Research Council (MRC)MR/K005464/1INP - CENTRE FOR COGNITIVE NEUROIMAGING