Adhesion molecule expression and phenotype of glial cells in the olfactory tract

Barnett, S. C. and Franceschini, I. A. (1999) Adhesion molecule expression and phenotype of glial cells in the olfactory tract. Advances in Experimental Medicine and Biology, 468, pp. 297-307. (doi: 10.1007/978-1-4615-4685-6_24) (PMID:10635038)

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These data illustrate that OBECs have a highly plastic nature in keeping with their need to respond rapidly to changing environmental cues. This relates to their required function in supporting axonal extension throughout life. Future studies using antibodies to PSA-NCAM and L-NGFr together with FACS sorting to purify the two types of OBEC should give us a clearer understanding of the lineage relationship of the two phenotypes. With purified populations of the astrocyte-like and Schwann cell-like OBEC we should be able to determine if these cells have different functions in vivo, using several approaches namely: i) identifying the growth factors that regulate their growth and differentiation, ii) measuring the ability of the purified cells to remyelinate the experimentally-created CNS lesions and iii) carry out more detailed cellular and molecular comparisons of the two phenotypes.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Barnett, Professor Susan
Authors: Barnett, S. C., and Franceschini, I. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Advances in Experimental Medicine and Biology
Publisher:Springer New York

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