The differentiation of glial cell progenitor populations following transplantation into non-repairing central nervous system glial lesions in adult animals

Crang, A.J., Franklin, R.J.M., Blakemore, W.F., Noble, M., Barnett, S.C., Groves, A., Trotter, J. and Schachner, M. (1992) The differentiation of glial cell progenitor populations following transplantation into non-repairing central nervous system glial lesions in adult animals. Journal of Neuroimmunology, 40(2-3), pp. 243-253. (doi:10.1016/0165-5728(92)90140-G) (PMID:1430154)

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Abstract

The non-repairing nature of the locally x-irradiated ethidium bromide (EB)-induced demyelinating white matter lesion has been further validated by showing that injections of two cultures which promote host remyelination of EB lesions in normal tissue do not do so in x-irradiated lesions. The behaviour of an oncogene-immortalized glial cell line and a growth-factor-expanded glial progenitor population have been examined following transplantation into the non-repairing EB lesion. Our studies indicate that the selected gell populations were eacable of establishing glial environments around demyelinated axons. Extensive oligodendrocyte remyelination with little astrocytic presence was observed in lesions transplanted with growth-factor-expanded optic nerve progenitors, while less extensive oligodendrocyte remyelination with the establishment of astrocyte-like cells was found in lesion transplanted with ts A58-SV40T immortalized glial cells. Prolonged expansion of both populations resulted in a loss of differentiation to normal glial phenotypes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barnett, Professor Susan
Authors: Crang, A.J., Franklin, R.J.M., Blakemore, W.F., Noble, M., Barnett, S.C., Groves, A., Trotter, J., and Schachner, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Neuroimmunology
Publisher:Elsevier
ISSN:0165-5728
ISSN (Online):1872-8421
Published Online:13 November 2002

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