Gene drive systems for insect disease vectors

Sinkins, S. P. and Gould, F. (2006) Gene drive systems for insect disease vectors. Nature Reviews Genetics, 7(6), pp. 427-435. (doi:10.1038/nrg1870) (PMID:16682981)

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The elegant mechanisms by which naturally occurring selfish genetic elements, such as transposable elements, meiotic drive genes, homing endonuclease genes and Wolbachia, spread at the expense of their hosts provide some of the most fascinating and remarkable subjects in evolutionary genetics. These elements also have enormous untapped potential to be used in the control of some of the world's most devastating diseases. Effective gene drive systems for spreading genes that can block the transmission of insect-borne pathogens are much needed. Here we explore the potential of natural gene drive systems and discuss the artificial constructs that could be envisaged for this purpose.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Sinkins, Professor Steven
Authors: Sinkins, S. P., and Gould, F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Reviews Genetics
Publisher:Nature Publishing Group
ISSN (Online):1471-0064

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