Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

Fielding, C. A. et al. (2017) Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation. eLife, 6, e22206. (doi:10.7554/eLife.22206) (PMID:28186488) (PMCID:PMC5367895)

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Abstract

The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel NK cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1,300 cell surface and ~7,200 whole cell proteins, we demonstrate that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors. US18 and US20 work in concert to suppress cell surface expression of the critical NKp30 ligand B7-H6 thus inhibiting NK cell activation. The US12 family is therefore identified as a major new hub of immune regulation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wilkie, Dr Gavin and Suarez, Dr Nicolas and Davison, Professor Andrew
Authors: Fielding, C. A., Weekes, M. P., Nobre, L. V., Ruckova, E., Wilkie, G. S., Paulo, J. A., Chang, C., Suárez, N., Davies, J. A., Antrobus, R., Stanton, R. J., Aicheler, R. J., Nichols, H., Vojtesek, B., Trowsdale, J., Davison, A. J., Gygi, S. P., Tomasec, P., Lehner, P. J., and Wilkinson, G. W.G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:eLife
Publisher:eLife Sciences Publications
ISSN:2050-084X
ISSN (Online):2050-084X
Published Online:10 February 2017
Copyright Holders:Copyright © 2017 Fielding et al.
First Published:First published in eLife 6: e22206
Publisher Policy:Reproduced under a Creative Commons License

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