Wounds that heal and wounds that don’t − the role of the IL-33/ST2 pathway in tissue repair and tumorigenesis

Millar, N. L. , O’Donnell, C., McInnes, I. B. and Brint, E. (2017) Wounds that heal and wounds that don’t − the role of the IL-33/ST2 pathway in tissue repair and tumorigenesis. Seminars in Cell and Developmental Biology, 61, pp. 41-50. (doi:10.1016/j.semcdb.2016.08.007)

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Abstract

IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation. Given the right combination of signals and cellular damage, stored IL-33 is released from the cell where it can interact with its receptor ST2, triggering danger-associated responses and act as a cellular “alarmin”. Whilst IL-33/ST2 signalling has been shown to induce potent pro-inflammatory responses that can be detrimental in certain disease states, a dichotomous, protective role of IL-33 in promoting wound healing has also emerged in multiple tissues types. This review will explore the current literature concerning this homeostatic role of IL-33/ST2 in tissue repair and also review its role in uncontrolled wound responses as seen in both fibrosis and tumorigenesis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Millar, Dr Neal
Authors: Millar, N. L., O’Donnell, C., McInnes, I. B., and Brint, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Seminars in Cell and Developmental Biology
Publisher:Elsevier
ISSN:1084-9521
ISSN (Online):1096-3634
Published Online:10 August 2016
Copyright Holders:Copyright © 2016 Elsevier Ltd.
First Published:First published in Seminars in Cell and Developmental Biology 61: 41-50
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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