microRNAs - key players in host-parasite interactions

Britton, C. (2017) microRNAs - key players in host-parasite interactions. Parasite Immunology, 39(2), e12418. (doi:10.1111/pim.12418) (PMID:28171701)

[img]
Preview
Text
137253.pdf - Accepted Version

269kB

Abstract

The discovery of the RNA interference (RNAi) gene-silencing pathway in 1998 revolutionized analysis of gene function (1). In a similar way, the identification of another class of small RNAs, microRNAs (miRNAs), has significantly impacted our understanding of how genes are regulated in response to developmental, metabolic and environmental changes. The first miRNA, lin-4, was identified in the free-living nematode Caenorhabditis elegans in 1993 (2), but it was not until the discovery of the highly conserved let-7 miRNA in C. elegans and higher organisms that the importance of these small RNAs in co-ordinating gene expression in a wide range of species was revealed (3).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Britton, Dr Collette
Authors: Britton, C.
Subjects:?? Immunomodulation ??
?? Parasite ??
?? microRNA ??
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Parasite Immunology
Publisher:Wiley
ISSN:0141-9838
ISSN (Online):1365-3024
Published Online:07 February 2017
Copyright Holders:Copyright © 2017 John Wiley and Sons Ltd
First Published:First published in Parasite Immunology 39(2): e12418
Publisher Policy:Reproduced in accordance with the publisher copyright policy

University Staff: Request a correction | Enlighten Editors: Update this record