microRNAs - key players in host-parasite interactions

Britton, C. (2017) microRNAs - key players in host-parasite interactions. Parasite Immunology, 39(2), e12418. (doi: 10.1111/pim.12418) (PMID:28171701)

137253.pdf - Accepted Version



The discovery of the RNA interference (RNAi) gene-silencing pathway in 1998 revolutionized analysis of gene function (1). In a similar way, the identification of another class of small RNAs, microRNAs (miRNAs), has significantly impacted our understanding of how genes are regulated in response to developmental, metabolic and environmental changes. The first miRNA, lin-4, was identified in the free-living nematode Caenorhabditis elegans in 1993 (2), but it was not until the discovery of the highly conserved let-7 miRNA in C. elegans and higher organisms that the importance of these small RNAs in co-ordinating gene expression in a wide range of species was revealed (3).

Item Type:Articles
Glasgow Author(s) Enlighten ID:Britton, Professor Collette
Authors: Britton, C.
Subjects:?? Immunomodulation ??
?? Parasite ??
?? microRNA ??
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Parasite Immunology
ISSN (Online):1365-3024
Published Online:07 February 2017
Copyright Holders:Copyright © 2017 John Wiley and Sons Ltd
First Published:First published in Parasite Immunology 39(2): e12418
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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