Britton, C. (2017) microRNAs - key players in host-parasite interactions. Parasite Immunology, 39(2), e12418. (doi: 10.1111/pim.12418) (PMID:28171701)
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Abstract
The discovery of the RNA interference (RNAi) gene-silencing pathway in 1998 revolutionized analysis of gene function (1). In a similar way, the identification of another class of small RNAs, microRNAs (miRNAs), has significantly impacted our understanding of how genes are regulated in response to developmental, metabolic and environmental changes. The first miRNA, lin-4, was identified in the free-living nematode Caenorhabditis elegans in 1993 (2), but it was not until the discovery of the highly conserved let-7 miRNA in C. elegans and higher organisms that the importance of these small RNAs in co-ordinating gene expression in a wide range of species was revealed (3).
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Britton, Professor Collette |
Authors: | Britton, C. |
Subjects: | ?? Immunomodulation ?? ?? Parasite ?? ?? microRNA ?? |
College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Parasite Immunology |
Publisher: | Wiley |
ISSN: | 0141-9838 |
ISSN (Online): | 1365-3024 |
Published Online: | 07 February 2017 |
Copyright Holders: | Copyright © 2017 John Wiley and Sons Ltd |
First Published: | First published in Parasite Immunology 39(2): e12418 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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