Adams, D. J. , Clark, J. H., Hansen, L. B., Sanders, V. C. and Tavener, S. J. (1998) Aromatic trifluoromethyldenitration and trifluoromethyldecyanation using trifluoromethyltrimethylsilane. Journal of the Chemical Society: Perkin Transactions 1(18), pp. 3081-3086. (doi: 10.1039/a805079a)
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Abstract
Activation of trifluoromethyltrimethylsilane by potassium fluoride in N,N-dimethylacetamide provides a powerful source of trifluoromethide which is capable of substituting aromatic nitro and cyano groups under nucleophilic conditions, albeit in low yield. The trifluoromethide generated in this system is also a potent base which leads to a number of interesting side reactions via deprotonation of the substrate.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Adams, Dave |
| Authors: | Adams, D. J., Clark, J. H., Hansen, L. B., Sanders, V. C., and Tavener, S. J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Journal of the Chemical Society: Perkin Transactions 1 |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 0300-922X |
| ISSN (Online): | 2050-8255 |
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